Prof Gert Kruger

Prof Gert Kruger

BScHons MSc PhD (PU for CHE) HDE - Senior Lecturer

Contact:
University Road
H-Block
Westville Campus
Office: 53 on the 3rd Floor

Tel: +27(0) 31 260 2181
Fax: +27(0) 31 260 3091

E-mail: kruger@ukzn.ac.za

Section: Organic Chemistry

Website: http://ggkm.ukzn.ac.za/Homepage.aspx

Areas of Specialty:

  • Chiral catalysis
  • Cage chemistry
  • Pharmaceutical applications of Cage compounds

Education and Training:

  • BSc(Hons) 1988, MSc 1991,
  • Chemistry, Potchefstroom University, South Africa.
  • PhD Organic Chemistry, 1996,
  • Chemistry, Potchefstroom University, South Africa.
  • Lecturer at UKZN, 1996,-
  • Visiting Professor, University of North Texas.
    Denton, USA, 2000.

Representative Publications:

  • Martins FJC, Viljoen AM, Kruger HG, Fourie L, Roscher J, Joubert JA and Wessels PL, Enantioselective
  • Synthesis of Amino Acids from Pentacyclo[5.4.0.02,6.03,10.05,9]undecane-8,11-dione, Tetrahedron,
    2001, 57 (8), 1601.
  • Kruger HG, Ab initio Mechanistic Study of the Protection of Alcohols and Amines with Anhydrides,
  • J. Mol. Struct. (Theochem), 2002, 577, 281.
  • Govender T, Hariprakasha HK, Kruger HG and Marchand AP, Synthesis and Transport Studies of a
    New Class of Cage-annulated Chiral Macrocycles, Tetrahedron: Asymmetry, 2003, 14(11), 1553.
  • Odisitse S, Jackson GE, Govender T, Kruger HG and Singh A, Chemical speciation of
    copper(II) diaminediamide derivative of pentacycloundecane - a potential anti-inflammatory
    agent, Dalton Trans., 2007, 1140.
  • Albericio F, Arvidson PI, Bisetty K, Giralt E, Govender T, Jali J, Kongsaeree P, Kruger HG and Prabpai S.
  • Trishomocubane amino acid as a -turn scaffold, Chem. Biol. & Drug Design, 2008, 71
  • Onajole OK, Govender K, Govender P, Van Helden PD, Kruger HG, Maguire GEM, Muthusamy K, Pillay M, Wiid I and Govender T, Pentacyclo-undecane derived cyclic tetra-amines: Synthesis and evaluation as potent anti-tuberculosis agents, Eur. J. Med. Chem., 2009, 44, 4297. (DOI http://dx.doi.org/10.1016/j.ejmech.2009.07.015))
  • Muthusamy K, Arvidsson PI, Govender P, Kruger HG, Maguire GEM, Govender T. Design and study of peptide-based inhibitors of amylin cytotoxicity. Bioorg. Med. Chem. Lett. 2010, 20 (4), 1360. (http://dx.doi.org/10.1016/j.bmcl.2010.01.004)
  • Muthusamy K, Albericio F, Arvidsson PI, Govender P, Kruger HG, Maguire GEM and Govender T. Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells. Biopolymers: Peptide Science, 2010, 94, 323. (DOI: 10.1002/bip.21370)
  • Shiri M, Zolfigol MA, Kruger HG and Tanbakouchian Z, Bis- and Trisindolylmethanes (BIMs and TIMs), Chem. Rev. 2010, 110 (4), 2250. (DOI: 10.1021/cr900195a).
  • Onajole OK, Govender P, van Helden PD, Kruger HG, Maguire GEM, Wiid I, Govender T, Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates, Eur. J. Med. Chem., 2010, 45 (5), 2075. ( doi:10.1016/j.ejmech.2010.01.046)
  • Chakka SK, Andersson PG, Maguire GEM, Kruger  HG, Govender T, Synthesis and Screening of Novel C1 Substituted Tetrahydroisoquinoline Derivatives for Asymmetric Transfer Hydrogenation Reactions, Eur. J. Org. Chem. 2010, 5, 972. (DOI: 10.1002/ejoc.200)
  • Peters BK, Chakka SK, Naicker T, Maguire GEM, Kruger HG, Andersson PG and Govender T. Synthesis of tetrahydroisoquinoline (TIQ)-diamine ligands and their application in asymmetric transfer hydrogenation, Tetrahedron Asymmetry, 2010, 21 (6), 679. ( doi:10.1016/j.tetasy.2010.04.017)
  • Bose PP, Chatterjee U, Hubatsch I, Artursson P, Govender T, Kruger HG, Bergh M, Johansson J, Arvidsson PI, In vitro ADMET and physical–chemical investigations of poly-N-methylated peptides designed to inhibit Abaggregation, Bioorg. Med. Chem. 2010, 18 (16), 5896.  (http://dx.doi.org/10.1016/j.bmc.2010.06.087)
    Pietersen LK, Govender P, Kruger HG, Maguire GEM, Govender T, Enzymatic Activation of a Peptide Functionalised Gold Nanoparticle System for Prodrug Delivery.  J. Nanoscience and Nanotechnology, 2010, 10, 1.  (doi:10.1166/jnn.2010.3600)
  • Chakka SK, Peters BK, Maguire GEM, Kruger HG, Andersson PG, Govender T, Iridium catalyzed asymmetric hydrogenation of olefins using TIQ phosphine-oxazoline ligands. Tetrahedron Asymmetry.  2010, 21 (18), 2295.  (doi:10.1016/j.tetasy.2010.07.032)
  • Naicker T, Petzold K, Singh T, Arvidsson PI, Kruger HG, Maguire GEM, Govender T. Novel tetrahydroisoquinoline based organocatalysts for asymmetric Diels–Alder reactions: insight into the catalytic mode using ROESY NMR and DFT studies, Tetr. Asym., 2010, 21, 2859.  (doi:10.1016/j.tetasy.2010.11.010)
  • Onajole OK, Coovadia Y, Govender T, Kruger HG, Maguire GEM, Naidu D, Singh N, and Govender P, In-vitro antifungal and antibacterial activities of pentacycloundecane tetra-amines, Chem. Biol. & Drug Design., 2011, 77, 295. (doi: 10.1111/j.1747-0285.2011.01055.x)

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